Synapticplasticity相关论文
目的:探究长期酒精摄入对小鼠小脑皮层苔藓纤维-颗粒细胞突触可塑性及运动功能的影响。方法:30只清洁级6~8周龄健康ICR小鼠(性别不......
Demonstration of synaptic and resistive switching characteristics in W/TiO2/HfO2/TaN memristor cross
In this study,resistive random-access memory (RRAM)-based crossbar arrays with a memristor W/TiO2/HfO2/TaN structure wer......
Steroid hormones play important roles in brain development and function.The signaling of steroid hor-mones depends on th......
Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neuron
Local signaling events at synapses or axon terminals are communicated to the nucleus to elicit transcriptional responses......
The hypothalamic paraventricular nucleus (PVN) is a crucial region involved in maintaining homeostasis through the regul......
AVP(4-8) Improves Cognitive Behaviors and Hippocampal Synaptic Plasticity in the APP/PS1 Mouse Model
Memory deficits with aging are related to the neurodegeneration in the brain,including a reduction in arginine vasopress......
Spatial and temporal plasticity of synaptic organization in anterior cingulate cortex following peri
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Objective Learning and memory is one of the most fundamental brain functions in the survival and development of human an......
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The effect and its potential mechanisms of STAT3 on synaptic plasticity in hippocampus of tmporal lo
Temporal lobe epilepsy(TLE)is the most common type of clinical refractory epilepsy,accounted for 60%....
Objective Alzheimers disease(AD)is the most common type of dementia,which seriously affects the life quality of the elde......
Objective Long-term potentiation(LTP)of synaptic transmission is thought to be a direct reflection of synaptic informati......
Derepression of tPA expression by knocking out NRSF enhances mature BDNF and upregulates hippocampal
Neuronal restrictive silencing factor (NRSF) is an epigenetic repressor with important role in regulating neurogenesis a......
Protein kinase C promotes NMDA receptor trafficking by indirectly triggering CaMKⅡ autophosphorylati
Regulation of neuronal NMDA receptor is critical in synaptic transmission and plasticity.Protein kinase C (PKC) promotes......
Metaplastic regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in t
In the main olfactory bulb recent history of activity input onto granule cells (GCs) can affect the strength of lateral ......
Its accepted that amyloid β-derived diffusible ligands(ADDLs)play a prominent role in triggering the early cognitive de......
Metabotropic glutamate receptor subtype 1 and 5 mediate opposite effects on pain-related spatial and
Objective It has been revealed that peripheral persistent nociception results in spatial and temporal synaptic plasticit......
Differential roles of ERK,JNK and p38 MAPK in pain-related spatial and temporal enhancement of synap
Objective It is known that chronic pain affects various higher brain functions including perception, emotion, cognition,......
Alzheimers disease(AD)is characterized by the progressive decline of memory and other cognitive functions.Increasing evi......
Low-density lipoprotein receptor-related protein 4(LRP4)is a member of the low-density lipoprotein receptor(LDLR)family....
The effects of enriched environment from birth on dendritic complexity and synaptic plasticity in CA
Enriched Environment (EE) is a well-established paradigm for naturally increasing neural activity in vivo.Studies have s......
Objective Hydrogen sulfide (H2S) has been classified as a third novel gasotransmitter signaling molecule following nitri......
GluN2B-containing NMDA receptors contribute to the beneficial effects of hydrogen sulfide on cogniti
Objective: Alzheimers disease (AD) is themost common formof dementia.Previous studies have demonstrated that hydrogen su......
The Role of Hippocampal structural synaptic plasticity in repetitive transcranial magnetic stimulati
Objective Repetitive transcranial magnetic stimulation (rTMS) could improve the cognitive functions in patients with Alz......
Effects of ethyl acetate extract from Cynomorim songaricum Rupr on synaptic plasticity via non-genom
Evidence have shown that estrogen is not only synthesized in gonadal glands but also in hippocampus,and its role in modu......
Lead(Pb)exposure impairs hippocampus related learning and memory by altering synaptic plasticity and
Lead(Pb)is an environmental neurotoxic metal.Pb exposure may cause neurobehavioral changes,such as learning and memory i......
The exact roles of acid-sensing ion channels(ASICs)in synaptic plasticity remain elusive.Here,we address the contributio......
Low intensity treadmill exercise enhances synaptic plasticity and CREB phosphorylation in the hippoc
Objective: To investigate the effects of low intensity treadmill exercise on cognitive behavior of rats and its underlyi......
Roles of acid-sensing ion channel 1a in synaptic plasticity in the hippocampus:Revisited by multi-el
Acid-sensing ion channels(ASICs)are proton-gated cation channels involved in a variety of physiological and pathological......
Parkinsons disease(PD)is the second most common neurodegenerative disease,a condition characterized by deficits in both ......
The effect of high frequency repetitive transcranial magnetic stimulation(rTMS)on the cognitive beha
Objective To observe the effect of high frequency repetitive transcranial magnetic stimulation(rTMS)on the cognitive beh......
Role of D1 and D2 signaling in regulating functional and structural Synaptic Plasticity in the Motor
In Parkinson disease(PD),the main pathological change is dopaminergic neurons death in SNc.Patients with PD have deficit......
Given the NMDA receptor(NMDAR)plays a central role in various brain functions,the trafficking of NMDAR in response to sy......
Objective: Fragile X syndrome(FXS)is a form of inherited mental retardation in humans that results from expansion of a C......
Neuroplasticity mechanism for the beneficial effects of olanzapine on schizophrenia-like spatial mem
Background: Schizophrenia patients exhibit a wide range of impairments in cognitive functions.Clinically, typical antips......
Effects of NR2A overexpression on prefrontal synaptic plasticity and prefrontal cortex-related memor
Objective N-methyl-D-aspartate receptors (NMDARs) play an important role in learning and memory.NR2A and NR2B subunits a......
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Spike timing-dependent plasticity of neocortical excitatory synapses on inhibitory interneurons depe
Repetitive correlated spiking can induce long-term potentiation (LTP) and long-term depression (LTD) of many excitatory ......
Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated imp
Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in Alzheimer disease (AD),the most co......
In recent years, a number of potential synapto-nuclear protein messengers have been characterized that are thought to be......
Physical exercise is known to be beneficial for preventing depression and neurodegenerative diseases.Animal studies have......
Objective To investigated the possibility that monocular deprivation also induces adaptive metaplasticity of tLTP induct......
In the cerebellum,long-term depression(LTD)of synaptic transmission from parallel fiber(PF)to Purkinje cell(PC)has been ......
Neuregulin 1(NRG1)is a trophic factor that acts by stimulating ErbB receptor tyrosine kinases and has been implicated in......
Majority of studies on synaptic and cognitive functions have been focusing on the critical role of calcium ion and its c......
high-salt(HS)diet is strongly associated with increased blood pressure and cardiovascular disease.It is well documented ......
Excessive synchronization of neurons in cerebral cortex is believed to play a crucial role in the emergence of neuropsyc......
Liuwei Dihuang decoction(LW),a classic formula in traditional Chinese medicine(TCM),has been used for nearly one thousan......
Activity-dependent synaptic plasticity plays a key role in the refinement of neural circuits and expression of behaviors......
